Memorial Sloan Kettering Monmouth

Middletown, NJ

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Accepting patients

MyeloMATCH Master Protocol

Master Screening and Reassessment Protocol (MSRP) for the NCI MyeloMATCH Clinical Trials
  • Genetic Sequencing
  • Phase 2
  • Leukemia Service
  • 24-295

Accepting patients

DFV890

A Phase 1b, Open Label, Multi-center, Dose Optimization and Dose Expansion Study to Assess the Safety and Efficacy of DFV890 in Adult Patients With Myeloid Diseases
  • NLRP3 Inhibitor
  • Phase 1
  • Has results
  • Leukemia Service
  • 23-210

Not currently accepting

SGR-2921

A First-In-Human, Phase 1, Dose Escalation Study of SGR-2921 as Monotherapy In Subjects With Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
  • CDC7 Inhibitor
  • Phase 1
  • Leukemia Service
  • 24-101

Accepting patients

Gilteritinib Combination Therapy

A Phase 1b Multi-center Study of the FLT3 Inhibitor Gilteritinib in Combination With the IDH1 Inhibitor Ivosidenib or the IDH2 Inhibitor Enasidenib for Patients With Relapsed or Refractory Acute Myeloid Leukemia Who Have Co-occurring FLT3/IDH1 or FLT3/IDH2 Mutations
  • IDH2 Inhibitor
  • IDH1 Inhibitor
  • Tyrosine Kinase (TK) Inhibitor
  • FLT3 Inhibitor
  • Phase 1
  • Leukemia Service
  • 22-174

Accepting patients

NX-5948

A Phase 1, Dose Escalation, and Cohort Expansion Study Evaluating NX-5948, a Bruton's Tyrosine Kinase (BTK) Degrader, in Adults With Relapsed/Refractory B-cell Malignancies
  • BTK Degrader
  • Phase 1
  • Has results
  • Leukemia Service
  • 24-178

Accepting patients

Azacitidine and Venetoclax for MRD

A Phase 2 Study of Azacitidine and Venetoclax to Treat Acute Myeloid Leukemia Patients With Measurable Residual Disease Before an Allogeneic Stem Cell Transplant
  • Chemotherapy
  • Hypomethylating Agents (HMA)
  • Minimal Residual Disease (MRD)
  • Phase 2
  • Leukemia Service
  • 24-347

Accepting patients

EVOLVE

Randomized, Phase III Study of Early Intervention With Venetoclax and Obinutuzumab Versus Delayed Therapy With Venetoclax and Obinutuzumab in Newly Diagnosed Asymptomatic High-Risk Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): EVOLVE CLL/SLL Study
  • BCL-2 Inhibitor
  • Monoclonal Antibody
  • CD20
  • Randomization
  • Phase 3
  • Lymphoma Service
  • 21-117

Accepting patients

Asciminib Combination Therapy

Protocol Number: HJKC3-0003. Treatment Free Remission After Combination Therapy With Asciminib (ABL001) Plus Tyrosine Kinase Inhibitors (TKI) in Chronic Phase Chronic Myeloid Leukemia (CP-CML) Patients Who Relapsed After a Prior Attempt at TKI Discontinuation
  • BCR-ABL1 Tyrosine Kinase Inhibitor
  • Tyrosine Kinase (TK) Inhibitor
  • Phase 2
  • Leukemia Service
  • 22-390

Accepting patients

RALLY-MF

RALLY-MF: A Phase 1b/2 Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of DISC-0974 in Participants with Myelofibrosis or Myelodysplastic Syndrome and AnemiaA Phase 1b/2a Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DISC-0974 in Participants with Myelofibrosis and Anemia
  • Monoclonal Antibody
  • Hemojuvelin (HJV)
  • Monotherapy
  • Randomization
  • Phase 1/2
  • Has results
  • Leukemia Service
  • 23-294

Accepting patients

TERN-701

A Phase 1 Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of TERN-701 in Participants With Chronic Myeloid Leukemia
  • Tyrosine Kinase (TK) Inhibitor
  • Phase 1
  • Has results
  • Leukemia Service
  • 24-225