Accepting patients
The Beat AML Trial
A Master Protocol for Biomarker-Based Treatment of AML (The Beat AML Trial)
- BCL-2 Inhibitor
- Hypomethylating Agents (HMA)
- Menin Inhibitor
- Phase 1/2
- Leukemia Service
- 17-135
Accepting patients
MyeloMATCH Master Protocol
Master Screening and Reassessment Protocol (MSRP) for the NCI MyeloMATCH Clinical Trials
- Genetic Sequencing
- Phase 2
- Leukemia Service
- 24-295
Accepting patients
DFV890
A Phase 1b, Open Label, Multi-center, Dose Optimization and Dose Expansion Study to Assess the Safety and Efficacy of DFV890 in Adult Patients With Myeloid Diseases
- NLRP3 Inhibitor
- Phase 1
- Has results
- Leukemia Service
- 23-210
Accepting patients
SGR-2921
A First-In-Human, Phase 1, Dose Escalation Study of SGR-2921 as Monotherapy In Subjects With Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
- CDC7 Inhibitor
- Phase 1
- Leukemia Service
- 24-101
Accepting patients
Gilteritinib Combination Therapy
A Phase 1b Multi-center Study of the FLT3 Inhibitor Gilteritinib in Combination With the IDH1 Inhibitor Ivosidenib or the IDH2 Inhibitor Enasidenib for Patients With Relapsed or Refractory Acute Myeloid Leukemia Who Have Co-occurring FLT3/IDH1 or FLT3/IDH2 Mutations
- IDH2 Inhibitor
- IDH1 Inhibitor
- Tyrosine Kinase (TK) Inhibitor
- FLT3 Inhibitor
- Phase 1
- Leukemia Service
- 22-174
Accepting patients
NX-5948
A Phase 1, Dose Escalation, and Cohort Expansion Study Evaluating NX-5948, a Bruton's Tyrosine Kinase (BTK) Degrader, in Adults With Relapsed/Refractory B-cell Malignancies
- BTK Degrader
- Phase 1
- Has results
- Leukemia Service
- 24-178
Accepting patients
REM-422
A Phase 1, Multicenter, Open-Label Study of REM-422, an MYB mRNA Degrader, in Patients With Relapsed/Refractory AML or Higher-Risk MDS
- MYB mRNA Degrader
- Phase 1
- Leukemia Service
- 24-102
Accepting patients
Azacitidine and Venetoclax for MRD
A Phase 2 Study of Azacitidine and Venetoclax to Treat Acute Myeloid Leukemia Patients With Measurable Residual Disease Before an Allogeneic Stem Cell Transplant
- Chemotherapy
- Hypomethylating Agents (HMA)
- Minimal Residual Disease (MRD)
- Phase 2
- Leukemia Service
- 24-347
Accepting patients
EVOLVE
Randomized, Phase III Study of Early Intervention With Venetoclax and Obinutuzumab Versus Delayed Therapy With Venetoclax and Obinutuzumab in Newly Diagnosed Asymptomatic High-Risk Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): EVOLVE CLL/SLL Study
- BCL-2 Inhibitor
- Monoclonal Antibody
- CD20
- Randomization
- Phase 3
- Lymphoma Service
- 21-117
Accepting patients
Asciminib Combination Therapy
Protocol Number: HJKC3-0003. Treatment Free Remission After Combination Therapy With Asciminib (ABL001) Plus Tyrosine Kinase Inhibitors (TKI) in Chronic Phase Chronic Myeloid Leukemia (CP-CML) Patients Who Relapsed After a Prior Attempt at TKI Discontinuation
- BCR-ABL1 Tyrosine Kinase Inhibitor
- Tyrosine Kinase (TK) Inhibitor
- Phase 2
- Leukemia Service
- 22-390